Thermo Scientific NanoDrop One & OneC
Thermo Scientific NanoDrop One & OneC


Quantify and qualify DNA, RNA, and protein samples with only 1-2 µL and have full-spectral data in seconds using the NanoDrop™ One Microvolume UV-Vis spectrophotometer.

  • Prevent costly delays – identify contaminants, obtain corrected concentrations, and enjoy success in your downstream applications
  • Collect data fast – Auto-Blank and Auto-Measure modes save time while organizing data
  • Save bench space – user-friendly local control with sleek, standalone design means no PC required

Call 6316-7490 for a demo today!


Discover more products to suit your laboratory needs from Thermo Scientific NanoDrop Product Guide here.


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Available with both pedestal and cuvette positions to expand experimental flexibility and increase the dynamic range. Measure dilute samples, perform kinetics experiments and take optical density measurements of bacterial cultures. Cuvette position includes temperature control and stirring.

Cuvette Option

Ergonomic, standalone design — integrated Android™ tablet eliminates the need for a separate computer and provides modern connectivity for seamless data transfer via Wireless*, Ethernet or USB.

Auto-Measure and Auto-Blank functions — multi-sample processing can be streamlined with instant measurements that occur when the pedestal arm is down. These functions can be turned ON or OFF with a single tap on the screen.

Wider dynamic range — no dilutions required for highly concentrated samples (dsDNA at 27,500 ug/µL) with auto-range pathlength technology.

 Integrated Learning Center — an archive of answers with technical support documents and educational animations at your fingertips.

  • Wide spectral range (190-850 nm) for measuring a variety of samples types:

– Peptides (205 nm)
– DNA and RNA (260 nm)
– Purified protein (280 nm)
– Toxicology assays and industrial dyes (490 nm)
– Gold nanoparticles (520 nm)
– Colorimetric protein assays (BCA 562 nm, Bradford 595 nm, Modified Lowry 650 nm, Pierce 660 660 nm)
– Optical Density measurements (600 nm)

  • Combining the patented** sample-retention system with cuvette capability accommodates low and high concentrations (2.0 – 27,500 ng/ µL dsDNA and 0.06 – 820 mg/mL BSA)
  • Pedestal measurements that require only 0.5 – 2 µL of your sample and do not require sample dilution, even for highly concentrated samples
  • Pre-configured methods for DNA, Protein A280, Microarray, Protein and Labels, Pierce 660, Bradford, BCA, and Lowry
  • User-friendly software that includes custom methods and data export capabilities
  • Instrument comes with 1-year warranty PLUS additional 1-year Limited Hardware Warranty (parts only)


**Patents US6628382 and US6809826

 Android is a trademark of Google Inc.

 For research use only. Not for diagnostic purposes. All NanoDrop instruments are approved to CE and UL/CSA.

NanoDrop One NanoDrop OneC
(with Additional Cuvette Position)
Instrument Control Built-in touchscreen
Minimum Sample Volume 1 µL
Limit of Detection (dsDNA) Pedestal: 2.0 ng/μL Pedestal: 2.0 ng/μL
Cuvette: 0.2 ng/μL
Limit of Detection (BSA (IgG) Pedestal: 0.06 (0.03) mg/mL Pedestal: 0.06 (0.03) mg/mL
Cuvette: 0.006 (0.003) mg/mL
Maximum Concentration (dsDNA) Pedestal: 27,500 ng/μL
Maximum Concentration (BSA (IgG) Pedestal: 820 (400) mg/mL
Measurement and Data Processing Time 8 seconds
Measurement Repeatability Typical: 0.002 A (1.0 mm path) or 1%CV, whichever is greater
( SD of 10 individual measurements at 0.97 A)
Wavelength Range 190 – 850 nm
Wavelength Accuracy ±1 nm
Photometric Range (10 mm equivalent) Pedestal: 0–550 A Pedestal: 0–550 A & Cuvette: 0–1.5 A
Photometric Accuracy 3% at 0.97 A, 302 nm   (Absorbance expressed at Abs/mm at 25 °C)
Light Source(s) Xenon flash lamp
Resolution (Spectral Bandwidth) ≤1.8 nm (FWHM at Hg 254 nm)
Pathlength 0.030 to 1.0 mm auto-ranging
Light Source Xenon flash lamp
Detector 2048-element CMOS linear image sensor
Dimensions (W × D × H) 20 × 25.4 × 32.3 cm
Weight 3.6 kg
Operating Voltage 12 V (DC)
Operating Power Consumption 12 – 18 W
Standby Power Consumption  5 W
Stirring NA 9 speeds
Temperature Control NA 37 °C
On-Board Control Operating System Android™
On-Board Control CPU Quad Core ARM® Cortex™-A9 Processor
On-Board Control Display 7-inch, 1280 × 800 high-definition color display
On-Board Control Touchscreen Multipoint capacitive touch
On-Board Control Gesture Recognition Single point, single point hold, swipe and pinch
On-Board Control Glove Compatibility Compatible with lab gloves
On-Board Control Internal Storage 32 GB flash memory
On-Board Control Audio Built-in speaker
Connectivity Three USB-A ports, Ethernet, Bluetooth® and Wi-Fi. (Only available on instruments with Wi-Fi/Bluetooth support)
PC Software Requirements Windows® 7 and 10, 64 bit
Accessory Support DYMO LabelWriter 450 printer, Bluetooth keyboard, mouse and barcode reader
Application Support Nucleic Acid A260, A260/A280, A260/A230 and Labeled Nucleic Acids; Protein A280 and A205, Protein Pierce 660, Protein Bradford, Protein BCA, Protein Lowry, Labeled Proteins, OD600, Kinetics, UV-Vis, and Custom Methods



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