Harbinger Biotechnology StarGazer-384™ Plate Reader

Harbinger’s StarGazer-384™ is a unique plate reader designed to study the thermal stability of proteins. Using patent-pending differential static light scattering technology, this instrument measures the amount of aggregated protein in a 384-well plate as a function of rising temperature.

This thermal-aggregation assay can be used for the following applications:

HTS of focused compound libraries
Validation of HTS hits
Buffer optimization
Identification of ligands for protein crystallization
QC of protein biologics
Characterization of membrane proteins
Comparison of stability of different constructs of a given protein, including SNPs [3].

The StarGazer-384 instrument has the following advantages over other products:

The thermal-aggregation assay is non-specific – i.e. it is not necessary to develop a dedicated assay for every protein.
Because the instrument employs the classical principle of light scattering to measure aggregated protein, it is not susceptible intrinsic fluorescence in proteins or compounds.
While differential scanning calorimetry can only be used to study one protein at a time, StarGazer-384 is designed for 384 samples in parallel.
StarGazer-384 has integrated software for image processing, graphical visualization and numerical analysis. The software automatically generates thermal-aggregation curves for all the samples and computes the T_agg representing each curve.

Item Code	Description
StarGazer-384	High-Throughput Protein Stability Analyzer